Final answer:
It is impossible to distinguish if an inertial frame is in motion or at rest through physical experiments due to the equivalence of inertial frames.
Explanation:
No, it is impossible to design any physical experiment to distinguish whether an inertial frame is in motion or at rest. According to the principle of equivalence of inertial frames, all inertial frames are considered equal, and no experiment can distinguish one preferred inertial frame from others.
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