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Which edit should be made to correct the sentence?

"The Colosseum in Rome, Italy which is considered one of the 'new' Seven Wonders of the World, is the largest amphitheater ever built and once could hold up to 50,000 spectators."

A. Delete the comma after Rome.
B. Insert a comma after Italy.
C. Delete the comma after World.
D. Insert a comma after built.