The frontal lobe tends to be smaller in individuals with severe depression, and abnormalities in the left frontal cortex are linked to the condition.
The frontal lobe tends to be smaller in individuals diagnosed with severe depression. Research shows that individuals with depression often exhibit decreased tissue volumes in the prefrontal and anterior cingulate cortices, as well as the hippocampal regions.
Furthermore, damage or abnormalities in the left frontal cortex have been linked to depression, as this region is more active during appetitive emotions like desire and interest.
Decreased activation in certain regions of the prefrontal cortex can inhibit its ability to suppress negative emotions, leading to more negative mood states in depressed individuals.
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