Final answer:
Frameshift mutations result from a change in the reading frame, causing significant impacts on protein functionality.
Explanation:
A frameshift mutation occurs when there is an insertion or deletion of nucleotides that is not a multiple of three, altering the reading frame of the genetic code. This change leads to a drastic effect on the encoded protein, often rendering it nonfunctional.
Learn more about Frameshift mutations and protein synthesis here:
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