Prokaryotic cells have a singular circular chromosome, whereas eukaryotic cells have linear chromosomes, leading to differences in genome packaging and gene regulation complexity.
Prokaryotic cells have a single circular chromosome, while eukaryotic cells have linear chromosomes. An advantage of eukaryotic genome packaging is increased stability and protection for the DNA due to the complex structure. However, a disadvantage is that it can make gene expression regulation more complex compared to prokaryotes.
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