O-negative blood is used as the universal donor in blood transfusions due to its compatibility with all blood types. In critical shortages, the next best choice for a patient with a different blood type would be AB-positive blood.
When shortages of donated blood occur, O-negative blood is given to patients because it is considered the universal donor and can be transfused to individuals of any blood type without eliciting an immune response. If O-negative blood supplies were depleted, the next-best choice for a patient with a different blood type in critical need of a transfusion would be AB-positive blood. This blood type is considered the universal acceptor and can receive blood from any blood type without complications.
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