Females need two copies of an X-linked allele to express the trait; otherwise, they are carriers. The allele combination XRX represents a female carrier of an X-linked disorder.
X-linked recessive disorders are disproportionately observed in males. Females need to inherit recessive X-linked alleles from both parents to express the trait; otherwise, they are typically unaffected carriers. For a female to be a carrier of an X-linked disorder, she must have the allele combination XRX.
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