To address the given question, we need to identify which chemokine is associated with the disease progression of AIDS from the provided options.
The options are:
A. Cx3CL1
B. CxCL1
C. CCR5
D. CxCR5
Chemokines are a family of small cytokines or signaling proteins secreted by cells. They play a significant role in immune responses by directing the movement of circulating leukocytes to sites of inflammation or injury.
Among the options given, the chemokine closely associated with the progression of AIDS is CCR5 (option C). CCR5 is a receptor that is found on the surface of certain white blood cells. This receptor is crucial in the context of HIV/AIDS because the CCR5 receptor acts as one of the primary entry points that HIV uses to infect host cells. Mutations in the CCR5 gene, such as the CCR5-Δ32 mutation, have been shown to provide resistance against HIV infection, underscoring the receptor's significant role in disease progression.
Therefore, the correct answer is:
C) CCR5
