Macbeth's relationship with Banquo is ironic due to Macbeth's hidden feelings of threat towards Banquo.
Macbeth's relationship with Banquo is ironic as Macbeth appears friendly towards Banquo while actually feeling threatened by him. For example, Macbeth pretends to be cordial with Banquo in public, even though he is plotting his demise behind the scenes.
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