To determine the correct routes of administration for Nitroglycerine, let's break down the options provided in each of the choices:
### Choice Analysis
1. SL, TM, TD
- SL: Sublingual (under the tongue)
- TM: Transmucosal (across mucous membranes)
- TD: Transdermal (through the skin-patch)
2. SL, SQ, IM
- SL: Sublingual (under the tongue)
- SQ: Subcutaneous (under the skin)
- IM: Intramuscular (into a muscle)
3. PO, SL, 10
- PO: Per Os (by mouth)
- SL: Sublingual (under the tongue)
- 10: This does not appear to be a valid medical route of administration.
4. IV, PO, SL
- IV: Intravenous (into a vein)
- PO: Per Os (by mouth)
- SL: Sublingual (under the tongue)
### Medical Knowledge
Nitroglycerine can be administered through the following routes based on its common medical use:
- Sublingual (SL): A common method for quick relief in angina (chest pain).
- Intravenous (IV): Used in more severe cases, such as acute heart failure or during surgeries.
- By mouth (PO): Oral administration is also a valid route though less common compared to SL and IV.
### Conclusion
Based on the analysis:
- The first choice contains one or more valid routes but includes methods that are not commonly associated with Nitroglycerine.
- The second choice includes methods that are typically not applicable to Nitroglycerine such as Subcutaneous and Intramuscular.
- The third choice includes an invalid method ("10").
- The fourth choice comprises all the valid and commonly used routes of administration for Nitroglycerine — Sublingual, Intravenous, and Per Os.
Therefore, the correct choice is:
IV, PO, SL.
