Ions struggle to pass through plasma membranes due to their ionic charge and the membrane's hydrophobic nature.
Ions have a difficult time getting through plasma membranes due to their ionic charge. While small ions could easily slip through membrane spaces, their charge prevents them from doing so as they cannot diffuse through the hydrophobic interior of the membrane. This is why ions like sodium, potassium, calcium, and chloride need special means to penetrate plasma membranes.
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