Final answer:
Self-interest impacted the ratification debate as Federalists and Anti-Federalists had differing views on the benefits of a strong central government.
Explanation:
Self-interest played a significant role in the debate over ratification of the Constitution. Those in favor of ratification, known as Federalists, argued that ratifying the Constitution would benefit individual self-interests by establishing a strong central government that could protect property rights and ensure stability. On the other hand, Anti-Federalists were wary of centralized power, fearing it could jeopardize states' rights and individual liberties.
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