Loop diuretics like spironolactone inhibit the reabsorption of Na+ and Cl- ions, leading to increased urination as a side effect.
Loop diuretics inhibit the reabsorption of Na+ and Cl- ions in the ascending limb of the loop of Henle. By interfering with these electrolytes' reabsorption, the medication causes an increased amount of electrolytes to be excreted in the urine.
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