Final answer:
Rheumatic fever is an autoimmune disorder caused by Streptococcus pyogenes that can damage joints and heart valves.
Explanation:
Rheumatic fever is a serious clinical sequela of an infection with Streptococcus pyogenes that can result in damage to joints or the valves of the heart. It is an autoimmune disorder that may start as strep throat. The inflammation of the heart valves caused by cross-reacting antibodies leads to scarring and stiffness of the valve leaflets, producing a characteristic heart murmur.
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