The Corey-House method allows the synthesis of alkanes through carbon-carbon bond formation, with advantages over the Wurtz reaction. Two pathways for the synthesis of 2-methylpentane from three carbon compounds are outlined.
Corey-House method: The synthesis involves coupling two alkyl groups through a new carbon-carbon bond formation to produce an alkane. This method allows the preparation of unsymmetrical alkanes.
Advantages over Wurtz reaction: Corey-House method gives higher selectivity for desired products, avoids the formation of symmetrical alkanes, and eliminates the need for excess halides.
Synthesis of 2-methylpentane: Pathway 1 involves the Corey-House synthesis of propyl iodide with ethyl lithium followed by a Grignard reaction with a propanal. Pathway 2 includes the Grignard reaction of propyl bromide with methylmagnesium chloride followed by aqueous acid workup.
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