Fever during an infection can be triggered by pyrogens altering the hypothalamus' setting, along with the release of specific cytokines and toxins from pathogens. This fever response enhances immune defenses to combat the infection more effectively.
A fever is a significant increase in body temperature that can be triggered by various factors during an infection. Pyrogens, which can be exogenous or endogenous, such as interleukin-1, interleukin-6, interferon-y, and tumor necrosis factor, play a crucial role in altering the hypothalamus' thermostat setting to induce fever.
Additionally, the release of specific cytokines during an inflammatory response and the toxins secreted by invading pathogens can both contribute to causing a fever. The body's response to infection aims to enhance the immune defenses by inhibiting pathogen growth and promoting the activity of immune cells, such as leukocytes, to fight off the infection.
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