Final answer:
Hamilton and Jefferson's political differences led to the creation of the first political parties in America.
Explanation:
True. The political differences between Alexander Hamilton and Thomas Jefferson did indeed give rise to the formation of the first political parties in the United States. Hamilton and his supporters formed the Federalist Party, advocating for a strong central government and an industrial economy, while Jefferson and his followers established the Democratic-Republican Party, promoting a more agrarian society and states' rights.
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