Final answer:
Histamine binding to H1 receptors triggers allergic responses, and a mutation hindering GTP hydrolysis in the G-protein's alpha subunit would amplify allergic reactions.
Explanation:
Histamine binds to the H1 G-protein-linked receptor to initiate various allergic responses such as itchiness, airway constriction, mucus secretion, and more. If a mutation prevents the hydrolysis of GTP in the associated G-protein's alpha subunit, it would lead to a more severe allergic response compared to normal signaling.
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