Why do individuals with spinocerebellar ataxia experience loss of muscle control, even though the ataxin-1 protein builds up only in the brain and spinal cord?

A. Inclusions can build up in all body systems and can cause debilitating effects.

Individuals with spinocerebellar ataxia experience loss of muscle control due to the accumulation of misfolded ataxin-1 protein linked to dysfunction in protein degradation mechanisms.

Explanation:

Individuals with spinocerebellar ataxia experience loss of muscle control because of the accumulation of misfolded ataxin-1 protein in the brain and spinal cord. Although the protein builds up only in specific regions, the disruption in protein degradation mechanisms due to ubiquitin-proteasome system dysfunction leads to widespread consequences.

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Why do individuals with spinocerebellar ataxia experience loss of muscle control, even though the ataxin-1 protein builds up only in the brain and spinal cord?A. Inclusions can build up in all body systems and can cause debilitating effects.

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Other Questions

Why do individuals with spinocerebellar ataxia experience loss of muscle control, even though the ataxin-1 protein builds up only in the brain and spinal cord?

A. Inclusions can build up in all body systems and can cause debilitating effects.