Answered

Why do individuals with spinocerebellar ataxia experience loss of muscle control, even though the ataxin-1 protein builds up only in the brain and spinal cord?

A. Inclusions can build up in all body systems and can cause debilitating effects.



Answer :

GinnyAnswer

Final answer:

Individuals with spinocerebellar ataxia experience loss of muscle control due to the accumulation of misfolded ataxin-1 protein linked to dysfunction in protein degradation mechanisms.


Explanation:

Individuals with spinocerebellar ataxia experience loss of muscle control because of the accumulation of misfolded ataxin-1 protein in the brain and spinal cord. Although the protein builds up only in specific regions, the disruption in protein degradation mechanisms due to ubiquitin-proteasome system dysfunction leads to widespread consequences.


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