11. Which one of the following drugs is considered a radical cure and tissue schizonticide in malaria management?
A. Chloroquine
B. Primaquine
C. Quinine
D. Mefloquine

12. Which antimalarial drug causes a typical syndrome called cinchonism?
A. Chloroquine
B. Quinine
C. Artemisinin
D. Coartem

13. The proportion of artemether to lumefantrine in their combination is:
A. 5:1
B. 1:5
C. 1:6
D. 6:1

14. The newer amphotericin B has all the following except:
A. Fewer side effects
B. Greater efficacy
C. Better concentration at the site of action
D. All
E. None

15. The renal toxicity caused by amphotericin B is exacerbated in the presence of:
A. Flucytosine
B. Gentamicin
C. Rifampicin
D. Minocycline

16. Among the given antifungal agents, which one is relatively associated with less drug interaction and fewer side effects?
A. Miconazole
B. Tioconazole
C. Itraconazole
D. Ketoconazole

17. Which one of the following is a nucleoside reverse transcriptase inhibitor?
A. Nevirapine
B. Efavirenz
C. Atazanavir
D. Abacavir

18. Among the alternatives given in question 17, which drug causes rare cases of fatal generalized hypersensitivity, and in patients with a history of this problem, the drug is prohibited for rechallenge?

19. Due to its greater side effects at higher doses, it is used in small doses to boost the effect of other protease inhibitors:
A. Atazanavir
B. Saquinavir
C. Ritonavir
D. Indinavir

20. Too toxic to use parenterally:
A. Neomycin
B. Nystatin
C. Kanamycin
D. A and B
E. All

21. This drug is a dihydrofolate reductase inhibitor:
A. Sulfonamide
B. Trimethoprim
C. Flucytosine
D. Chloramphenicol

22. Not recommended for use in children:
A. Cefaclor
B. Ciprofloxacin
C. Tetracycline
D. A and C
E. B and C

23. This class of drug is associated with nephrotoxicity, ototoxicity, and neurotoxicity:
A. Aminoglycoside
B. Macrolide
C. Lincosamide
D. Cephalosporine

24. It is a good agent for dual infection of bacteria and amebiasis:
A. Gentamicin
B. Paromomycin
C. Tobramycin
D. Amikacin



Answer :

Final answer:

Primaquine is a radical cure for malaria, quinine causes cinchonism, and the proportion of artemether to lumefantrine is 1:6.


Explanation:

Primaquine is considered a radical cure and tissue schizonticide in malaria management. It belongs to the class of 8-aminoquinolines and is unique due to its anti-hypnozoite and gametocytocidal activities. It is known to cause methemoglobinemia and hemolysis in G6PD deficient individuals.

Quinine causes a typical syndrome known as cinchonism. Cinchonism is characterized by symptoms like tinnitus, headache, nausea, and vision disturbances.

The proportion of artemether to lumefantrine in their combination is 1:6, making it an effective antimalarial treatment option. This combination is widely used for the treatment of malaria.


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