Enzymes are affected by pH levels; the enzyme from a lower pH environment would likely denature in a higher pH stomach environment.
Enzymes are affected by the pH of their environment. The optimum pH for an enzyme is the pH at which it works best due to maintaining its native tertiary structure. If an enzyme from a lower pH environment, such as the blood, enters a higher pH environment like the stomach, it will likely denature and lose its functionality because the extreme pH disrupts its structure.
Enzymes like pepsin in the stomach work best at low pH around 1.5, while enzymes like trypsin in the small intestine work optimally at higher pH around 8. Extreme pH levels can lead to the denaturation of enzymes, rendering them ineffective in catalyzing reactions.
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