Final answer:
Mixing alcohol with pain relievers increases the risk of overdose due to their combined depressant effects on the central nervous system.
Explanation:
Alcohol can increase the risk of overdose when taken with pain relievers due to their combined depressant effects on the central nervous system. Depressants such as analgesics and sedatives can lead to drowsiness, relaxation, and a decrease in pain, and when mixed with alcohol, can result in dangerous outcomes including physical dependence and fatalities.
The interaction between alcohol and antidepressants or antihistamines can also have adverse effects, but the risk of overdose is notably higher when alcohol is combined with medications like pain relievers.
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