Answer :

To simplify the given expression:
[tex]\[ \left(\frac{\left(-x^2 y^3\right)^{-2}\left(2 x y^5\right)^2}{\left(-3 x^3 y^4\right)^4\left(2 x^6 y^{-2}\right)^{-1}}\right)^{-3} \][/tex]
let's break it down step-by-step.

1. Simplify the numerator [tex]\(\left(-x^2 y^3\right)^{-2}\left(2 x y^5\right)^2\)[/tex]:

[tex]\[ \left(-x^2 y^3\right)^{-2} = \left(-1 \cdot x^2 \cdot y^3\right)^{-2} = (-1)^{-2} \cdot (x^2)^{-2} \cdot (y^3)^{-2} = 1 \cdot x^{-4} \cdot y^{-6} = x^{-4} y^{-6} \][/tex]

[tex]\[ \left(2 x y^5\right)^2 = 2^2 \cdot (x)^2 \cdot (y^5)^2 = 4 \cdot x^2 \cdot y^{10} = 4x^2 y^{10} \][/tex]

Now, multiply these results together:

[tex]\[ x^{-4} y^{-6} \cdot 4 x^2 y^{10} = 4 \cdot x^{-4+2} \cdot y^{-6+10} = 4 \cdot x^{-2} \cdot y^4 \][/tex]

2. Simplify the denominator [tex]\(\left(-3 x^3 y^4\right)^4 \left(2 x^6 y^{-2}\right)^{-1}\)[/tex]:

[tex]\[ \left(-3 x^3 y^4\right)^4 = (-3)^4 \cdot (x^3)^4 \cdot (y^4)^4 = 81 \cdot x^{12} \cdot y^{16} = 81x^{12} y^{16} \][/tex]

[tex]\[ \left(2 x^6 y^{-2}\right)^{-1} = \frac{1}{2 x^6 y^{-2}} = \frac{1}{2} \cdot x^{-6} \cdot y^2 = \frac{1}{2} x^{-6} y^2 \][/tex]

Now, multiply these results together:

[tex]\[ 81 x^{12} y^{16} \cdot \frac{1}{2} x^{-6} y^2 = 81 \cdot \frac{1}{2} \cdot x^{12-6} \cdot y^{16+2} = \frac{81}{2} \cdot x^6 \cdot y^{18} = \frac{81}{2} x^6 y^{18} \][/tex]

3. Rewrite the entire fraction and simplify:

[tex]\[ \frac{4x^{-2} y^4}{\frac{81}{2} x^6 y^{18}} = \frac{4x^{-2} y^4 \cdot 2}{81 x^6 y^{18}} = \frac{8 x^{-2} y^4}{81 x^6 y^{18}} = \frac{8}{81} \cdot \frac{x^{-2}}{x^6} \cdot \frac{y^4}{y^{18}} \][/tex]

Simplify further:

[tex]\[ = \frac{8}{81} \cdot x^{-2-6} \cdot y^{4-18} = \frac{8}{81} x^{-8} y^{-14} \][/tex]

4. Apply the outer exponent [tex]\(-3\)[/tex]:

[tex]\[ \left(\frac{8}{81} x^{-8} y^{-14}\right)^{-3} = \left(\frac{81}{8} \cdot x^8 y^{14}\right)^3 = \left(\frac{81}{8}\right)^3 \cdot (x^8)^3 \cdot (y^{14})^3 = \frac{81^3}{8^3} \cdot x^{24} y^{42} \][/tex]

Calculate [tex]\(81^3\)[/tex] (note: [tex]\(81 = 3^4\)[/tex], so [tex]\(81^3 = (3^4)^3 = 3^{12}\)[/tex]):

[tex]\[ 81^3 = 531441 \][/tex]

Calculate [tex]\(8^3\)[/tex]:

[tex]\[ 8^3 = 512 \][/tex]

Putting it all together:

[tex]\[ \left(\frac{81}{8}\right)^3 x^{24} y^{42} = \frac{531441}{512} x^{24} y^{42} \][/tex]

Thus, the final simplified expression is:

[tex]\[ \boxed{\frac{531441}{512} x^{24} y^{42}} \][/tex]