A 45-year-old patient with depression has a history of seizures. Which antidepressant should be used with caution in this patient due to an increased risk of seizures, especially at high doses?

A. Mirtazapine (Remeron)
B. Amitriptyline (Elavil)
C. Paroxetine (Paxil)
D. Bupropion (Wellbutrin)
E. Duloxetine (Cymbalta)

In a 45-year-old patient with depression and a history of seizures, Bupropion (Wellbutrin) should be used with caution due to an increased risk of seizures at high doses.

Explanation:

Bupropion (Wellbutrin) should be used with caution in a 45-year-old patient with depression and a history of seizures due to an increased risk of seizures, especially at high doses. Bupropion is known to lower the seizure threshold, making it a risky choice for patients with a history of seizures.

Mirtazapine (Remeron), amitriptyline (Elavil), Paroxetine (Paxil), and Duloxetine (Cymbalta) are other antidepressants that may be considered as safer alternatives for patients with a history of seizures.

Learn more about Antidepressants and Seizure Risk here:

https://brainly.com/question/37485941