Final answer:
The Powhatan Confederacy interacted with the Jamestown settlers in Virginia during early colonization.
Explanation:
The tribal confederacy who came into contact with the Jamestown settlers was the Powhatan. The Powhatan Confederacy, led by Chief Powhatan, was a powerful alliance of Native American tribes in the Virginia region during the early colonial period. They interacted with the Jamestown settlers and played a significant role in the early history of English colonization in America.
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