Answer :
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The reason why the allele for sickle-cell disease remains at a relatively high level in the population is because it confers protection from malaria to carriers. This relationship between sickle-cell disease and malaria provides a selective advantage in regions where malaria is prevalent.
By having one copy of the sickle-cell allele, individuals are less likely to suffer severe consequences of malaria infection, leading to a higher chance of survival compared to individuals without the allele. This selective advantage results in the persistence of the sickle-cell allele in these populations despite the harmful effects of having two copies of the allele, which cause sickle-cell disease.
In summary, the allele for sickle-cell disease remains prevalent in certain populations due to its role in providing resistance to malaria, showcasing how complex interactions between genetic traits and environmental factors can influence allele frequencies in a population.