Answer:
Option 2, spread to or invaded other tissue
Explanation:
Metastasis is a medical term, usually referring to a cancer, describing the spread or invasion of a tumor from its primary site to a secondary location, which can be an entirely separate organ or simply another area beyond where it originated.
This term comes from a combination of two word roots. The prefix meta- comes from Greek and can mean change, alteration, higher, and beyond. The suffix -stasis in this case refers to positioning or standing. With this the definition can be derived. Metastasis is a change in position beyond its point of origin; the tumor has migrated from one place to another.
Thus, option 2 is the answer; no metastasis means the tumor has not spread to or invaded other tissue. The term for this is "in situ."
