The effectiveness of antidepressants is best observed in patients with mild depression, with medications like Prozac, Zoloft, Celexa, Lexapro, and Cymbalta showing success rates between 24% and 31%. A combination of medication and psychotherapy is commonly recommended for treating depression.
The patients who have responded best to antidepressants, according to psychologist Irving Kirsch's meta-analysis, are those with mild depression. Patients with severe depression have shown to respond less to antidepressant treatment compared to those with mild to moderate depression.
When analyzing the effectiveness of antidepressants, it was found that Prozac, Zoloft, Celexa, Lexapro, and Cymbalta had success rates ranging between 24% and 31%. Despite some improvements being attributed to placebo effects, these medications have proven to be effective, especially in the short term.
A combination of medication and psychotherapy is often the most effective treatment for depression, with up to 70% of people with depression responding well to medication.
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