Final answer:
The struggle between Federalists and Anti-Federalists during the US Constitution ratification focused on national vs. state power.
Explanation:
The Federalists and Anti-Federalists engaged in a significant struggle during the ratification of the US Constitution. The Federalists, including figures like James Madison and Alexander Hamilton, supported a strong national government and the Constitution's ratification. On the other hand, the Anti-Federalists feared excessive central government power and advocated for states' rights and decentralized authority.
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