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What are the first symptoms commonly observed in individuals with Stiff Person Syndrome (SPS)?
a) Muscle stiffness and rigidity in the trunk or limbs.
b) Intermittent muscle spasms.
c) Fatigue and anxiety.
d) Difficulty with balance and coordination.



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The answer is:  a) Muscle stiffness and rigidity in the trunk or limbs.

Stiffness in the trunk is a hallmark symptom of Stiff Person Syndrome [3]. While other options may appear later in the disease progression, initial signs typically focus on muscle stiffness and rigidity.

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