If the osmotic pressure of the blood were increased above normal levels, which of the following volumes would also increase?

A. Intracellular fluid volume
B. Interstitial fluid volume
C. Blood volume
D. Total body water



Answer :

Let's go through the given information step-by-step to answer the question about which volume would increase due to an increase in osmotic pressure of the blood.

### Given Information:
1. Plasma Volume: 3 L, 20% of ECF
2. Interstitial fluid (IF): Volume 12 L, 80% of ECF
3. Extracellular fluid (ECF): Volume 15 L, 20% of body weight
4. Total body water: Volume 40 L, 60% of body weight
5. Intracellular fluid (ICF): Volume = 25 L, 40% of body weight

### Understanding Osmotic Pressure:
Osmotic pressure is the pressure needed to prevent the flow of water through a semipermeable membrane, driven by differences in solute concentration. If osmotic pressure in the blood increases, water will tend to move into the bloodstream (plasma) from surrounding areas to balance out the solute concentration.

### Step-by-Step Analysis:
1. Blood (Plasma) Volume: If the osmotic pressure of the blood increases, water will move from the interstitial fluid (IF) into the blood. This increases the plasma volume because more fluid is pulled into the blood vessels.

2. Interstitial Fluid Volume: As water moves into the blood vessels, the volume of the interstitial fluid will decrease. This is because the fluid is being drawn out to balance the osmotic pressure.

3. Extracellular Fluid Volume (ECF): The ECF volume includes both plasma and interstitial fluid. Although the plasma volume increases, the interstitial fluid volume decreases, leading to an overall negligible change in the ECF volume.

4. Total Body Water: The total body water remains constant because the movement of water is internal, redistributing between compartments but not resulting in a net gain or loss of water in the body.

5. Intracellular Fluid Volume (ICF): There is no direct effect on the intracellular fluid volume because the osmotic pressure increase is specifically within the blood (extracellular compartment).

### Conclusion:
Based on the understanding of fluid shifts in response to increased osmotic pressure of the blood, the blood volume (i.e., the plasma volume) will increase.

The other volumes will either remain unchanged or, in the case of interstitial fluid, will decrease. Total body water also does not change as it is the sum of all water within the body, and intracellular fluid remains unaffected in this scenario.