Answer :
Final answer:
The Anglo-Powhatan Wars were significant conflicts between English colonists and Native Americans, culminating in the Jamestown Uprising of 1622 and the transformation of Virginia into a royal colony.
Explanation:
The significance of the Anglo-Powhatan Wars was the intense conflict between the English colonists and the Powhatan Confederacy of Native Americans in the early 17th century.
The Jamestown Uprising of 1622 was when the Powhatan Indians, led by Opechancanough, launched a coordinated series of attacks along the James River, killing 347 settlers, a quarter of the total population.
Opechancanough's actions eventually led to the dissolution of the Virginia Company, making Virginia a royal colony, and a treaty was signed in 1632, marking the end of significant hostilities between the Powhatan and the English.
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