Answered

ANRS Occupational Competency Assessment

Question:

A central concept of serologic testing is:

a. Manifestation of a rise in antibody titer

b. Antigen-antibody interaction

c. Quantitation of antigen titer

d. Determination of antibody composition



Answer :

Final answer:

The central concept in serologic testing is antigen-antibody interaction, crucial for detecting exposure to pathogens through specific binding. Measuring changes in antibody titer over time aids in distinguishing infections and monitoring immune responses.


Explanation:

Antigen-antibody interaction is a central concept in serologic testing. This interaction forms the basis for many diagnostic tests to detect exposure to specific pathogens through the specificity of antigen-antibody binding.

Antibodies produced by the immune system bind specifically to antigens, leading to the formation of visible matrices in agglutination tests or quantification of antigen titer in assays like ELISA.

Measuring changes in antibody titer over time can help distinguish current infections from past ones and monitor the immune system's response to pathogens.


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