Norepinephrine (NE) is the primary neurotransmitter secreted by most sympathetic post-ganglionic axons, binding to adrenergic receptors to produce various effects.
Norepinephrine (NE) is the neurotransmitter secreted by most sympathetic post-ganglionic axons. These postganglionic fibers release norepinephrine onto their target tissues, binding to alpha and beta adrenergic receptors to produce excitatory or inhibitory effects.
For example, the sympathetic postganglionic neurons release norepinephrine, which stimulates heartbeat, raises blood pressure, dilates pupils, and dilates the trachea and bronchi as part of the sympathetic response.
In contrast, sympathetic fibers that project to sweat glands and to blood vessels associated with skeletal muscles release acetylcholine (ACH), which binds to muscarinic receptors, causing a different response.
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